The 12th Workshop on Statistics, Mathematics and Computation - WSMC12, will be hosted by the University of Beira Interior in collaboration with Center of Mathematics and Applications of University of Beira Interior, Center of Statistics and it Applications of University of Lisbon and Universidade Aberta, continuing in the spirit of eleven earlier meetings. The format for the meeting will include plenary talks, organized sessions, and sessions with contributed talks and posters. The workshop includes keynote presentations by renowned scientists. The workshop will provide an opportunity to learn about the latest statistical, mathematical and computational methodologies. Another goal of the workshop is to strengthen relationships in the statistical and mathematical community and researchers who apply statistics and mathematics in other fields. Students are encouraged to participate and present their projects to conference attendees.